Custom Design & Synthesis

When flexibility meets quality and speed.

Service Description

AmRNA provides custom RNA synthesis services designed to support research from early screening through advanced in vitro and in vivo studies. Our workflow combines sequence design, optimized in vitro transcription, purification and quality control to deliver high-quality RNA tailored to your application.

With flexible sequence, modification, scale and formulation options, we utilize our validated platform to help researchers obtain the RNA (mRNA, saRNA, circular RNA, siRNA, sgRNA, etc) with speed and quality.

Explore Our Services

Custom mRNA

Research-grade mRNA with customizable sequence, UTRs, cap structure, nucleotide modification and poly(A) tail design.

Self-amplifying RNA (saRNA)

Custom saRNA constructs for applications requiring intracellular RNA amplification and extended protein expression.

Circular RNA (circRNA)

Custom circular RNA synthesis for applications focused on enhanced RNA stability and prolonged expression.

Other RNA formats

Chemical synthesis of siRNA, gRNA, sgRNA are also available. Other customized sequence variants, constructs and special designs available upon request.

Key Highlights

Custom sequence design and optimization

Special AI design tool to support custom sequence design and optimization towards better mRNA expression and stability.

Cap 1 and modified nucleotide options

Natural Cap1 structure can be synthesized by VCE or direct synthesis with cap analog. Various nucleotide modification can be chosen for better stability and lower immunogenicity.

Advanced purification with stringent QC

All synthesis will be purified through affinity purification (HPLC or oligo-dT) to achieve the best expression. Special purification towards immunogenic dsRNA is also available for in vivo use. Apart from standard release QC, more than 15 optional tests can be added for comprehensive CQA pannel.

Flexible scale from research screening to larger studies

For mRNA, saRNA and circRNA synthesis, we provide from 1mg to 1g to cover from discovery to pre-clinical development. Chemically synthesized short RNA can be ordered from 2OD. For high throughput mRNA synthesis of 10 sequences or more, our HT platform support 100ug/seuqence in 2-3 weeks.

Fast and responsive project turnaround

All the projects are supported by dedicated manager with guaranteed reply in 24h. Depending on the sequence complexity and length, custom synthesis can be completed as fast as 3 weeks.

Support for downstream LNP formulation

Learn about our LNP formulation service.

Your sequence to A-Grade RNA

Send us your sequence or project requirements and our team will help define the optimal synthesis strategy.

Request Custom Synthesis