Cre mRNA

Cre NLS mRNA (N1-Me-PseudoUTP) is capable of expressing Cre recombinase protein with nuclear localization signal. Cre recombinase is a type I topoisomerase of bacteriophage P1, which catalyzes site-specific recombination of DNA between loxP sites, resulting in DNA deletion and translocation. This product can be used for conditional gene knockout.

This mRNA features following structure: 

• Cap 1 (N7-methylguanosine Cap) with high capping efficiency 
• Poly(A) tail with 100 consecutive A 
• 5’ and 3’ UTR with proven efficient translation 
• ORF with codon optimization
• N1-methyl-pseudouridine modification

Competitive advantage of AmRNA product:

At AmRNA, we are committed to delivering ready-to-use mRNA of the highest quality standards (only A grade). Each mRNA is produced using state-of-the-art industrial synthesis and purification technologies, ensuring ultra-high purity, capping efficiency, and poly(A) tail integrity. Residual impurities such as protein, DNA, and dsRNA are reduced to trace levels to minimize potential immunogenicity. Our comprehensive quality control panel rigorously verifies every critical attribute to ensure batch-to-batch consistency, ensuring data reproducibility in both in vitro and in vivo applications.